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KMID : 0390320130230020133
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Chungbuk Medical Journal
2013 Volume.23 No. 2 p.133 ~ p.143
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Clinicopathologic Analysis of Breast Cancer According to Molecular Subtypes
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Han Seung-Wan
Lee Ho-chang
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Abstract
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Purpose: Treatment and prognosis of the breast cancer can be affected by molecular subtype determined by gene expression profiling as well as stage. Classification according to immunohistochemistry (IHC) results is consistent with the molecular subtype. The purpose of this study is to classify subtypes according to IHC and to analyze the differences in clinicopathologic features among the subtypes.
Materials and Methods: Subtypes were determined by IHC expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2) and ki-67 index in 223 cases of invasive ductal carcinoma: luminal A (LA), luminal B (LB), HER2-enriched (HE), and triple negative (TN). We analyzed the association with the subtypes and clinicopathologic characteristics.
Results: Nuclear and histologic grades and p53 overexpression were the highest in HP and TN, followed by LB and LA. Breast cancer with no ductal carcinoma in situ component was more frequently observed in TN than the other subtypes. Pathologic T stage of TN was higher than those of LA and LB. Ki-67 proliferation indices of TN were higher than those of other subtypes. Pathologic N stage and patients’ age were not significantly different among subtypes.
Conclusion: This study showed each subtype had its specific clinicopathologic features. It will help to select the most effective way to predict the prognosis and determine the treatments of patients with breast cancer.
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KEYWORD
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Breast cancer, Immunohistochemistiry, Molecular subtype, Pathology
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